Nocdurna is a brand-name medication prescribed to treat nocturia, a condition characterized by frequent nighttime urination. It contains the active ingredient desmopressin acetate and is classified as an antidiuretic.
The FDA has approved Nocdurna for adults who wake up at least twice per night to urinate due to nocturnal polyuria, a condition where the kidneys produce excessive urine during the night. Before starting Nocdurna, it’s recommended to:
Consider possible causes of frequent urination during the night, such as drinking a lot of fluids before bed, taking a diuretic (water pill) late in the day, or other treatable causes.
Confirm a nocturnal polyuria diagnosis with a 24-hr urine collection.
Nocdurna is available as a sublingual tablet, which dissolves under the tongue for quick absorption.
Prescription required. Can not be split. Product of UK/EU. Shipped from United Kingdom of Great Britain and Northern Ireland. Nocdurna is also marketed internationally under the name Noqdirna.
Prescription required. Can not be split. Product of UK/EU. Shipped from United Kingdom of Great Britain and Northern Ireland. Nocdurna is also marketed internationally under the name Noqdirna.
To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3-month supply or the closest package size available based on your personal prescription. read more
Nocdurna may cause mild or serious side effects. If you experience side effects, consult your doctor or pharmacist for guidance.
Mild side effects may include:
Dry mouth
Dizziness
Headache
Edema (fluid buildup): swelling in legs or feet, bloating, rapid weight gain
Some mild side effects may resolve within a few days. If they persist or worsen, contact your doctor. If you develop a skin rash or hives, it’s best to contact your healthcare provider before continuing the medication as this may be a sign of an allergic reaction.
Serious side effects (less common) may include:
Hyponatremia (low sodium): hyponatremia, also known as low blood sodium, is a condition where the level of sodium in your blood is lower than normal. A normal blood sodium level is between 135 and 145 milliequivalents per liter (mEq/L). Signs of low sodium levels include fatigue, confusion, dizziness, nausea, or muscle spasms. In some cases, hyponatremia can be life-threatening. It’s important to attend follow-up appointments and regularly monitor blood sodium levels while taking Nocdurna.
Severe allergic reactions (e.g., swelling in face, trouble breathing)
For severe symptoms, call 911 or seek emergency help immediately. You can also report side effects to the FDA through MedWatch.
Before starting or restarting NOCDURNA (desmopressin acetate), it’s vital to ensure that your sodium levels have been checked and they are in the normal range.
Individual dosage recommendations may vary. Standard dosing recommendations for adults are as follows:
Women: 27.7 mcg once daily, 1 hour before bed, placed under the tongue without water.
Men: 55.3 mcg once daily, 1 hour before bed, placed under the tongue without water.
Clinical trials suggest females may be more sensitive to the effects of Nocdurna and experienced higher rates of hyponatremia when using a 55.3 mcg dose. For this reason, a lower dose is often recommended.
Let the tablet fully dissolve under the tongue. Patients should empty their bladder before bed and limit fluids from 1 hour before until 8 hours after taking the medication.
Common questions and answers about NOCDURNA (desmopressin acetate):
NOCDURNA (desmopressin acetate) is a fast-acting medication and usually starts working within 30 minutes after you take it. The effects often last about six hours.
The content on this page is for informational and educational purposes only and does not constitute professional medical advice. Patients should not use the information presented on this page for diagnosing a health-related issue or disease. Before taking any medication or supplements, patients should always consult a physician or qualified healthcare professional for medical advice or information about whether a drug is safe, appropriate or effective.