Ibsrela (tenapanor) is a prescription medication used in adults to treat Irritable Bowel Syndrome with Constipation (IBS-C). It works by inhibiting the sodium/hydrogen exchanger 3 (NHE3) in the intestines, reducing the absorption of sodium and increasing the amount of fluid retained in the colon, which can help relieve constipation and discomfort associated with IBS-C.
Prescription required. Product of Canada. Shipped from Canada.
To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3-month supply or the closest package size available based on your personal prescription. read more
Ibsrela (tenapanor) Risks: Ibsrela can cause electrolyte imbalances due to drawing additional fluid to the digestive tract. This can cause systemic dehydration, which has the potential to be deadly. This risk may be elevated in pediatric patients, and Ibsrela is not recommended for individuals under the age of 18.
Diarrhea: Diarrhea is a common side effect, especially during the first week of treatment. Severe diarrhea can lead to dehydration, which requires immediate medical attention. Stay hydrated and contact your healthcare provider if diarrhea becomes severe.
Dosage: The typical dose is 50 mg, taken twice daily before breakfast and dinner. If a dose is missed, resume the regular dose at your next scheduled time. Do not take a double dose.
Contraindications: Ibsrela is directly contraindicated in children under 6 and is not recommended for individuals under the age of 18.
Ibsrela should be avoided if there is a known or suspected blockage in the digestive system.
Side effects of Ibsrela (tenapanor) reported in clinical trials include:
Common Side Effects:
Diarrhea (16% of patients)
Stomach bloating (3% of patients)
Gas (3% of patients)
Dizziness (2% of patients)
Some trial participants also reported unusual stomach sounds.
If any of these symptoms persist or worsen, inform your healthcare provider immediately.
Serious Side Effects: Seek emergency assistance if you experience:
Severe dehydration (symptoms: dry skin, extreme thirst, fast heartbeat, confusion, fainting)
Severe diarrhea
Rectal bleeding
How long does it take for Ibsrela (tenapanor) to work? Ibsrela (tenapanor) may start improving symptoms like constipation and stomach pain within one week, but it can take longer in some instances. Contact your healthcare provider if you are concerned about its effectiveness.
Does Ibsrela (tenapanor) cause weight gain or loss? Ibsrela does not cause weight gain or loss directly. However, diarrhea (a common side effect) can lead to unintentional, unsafe weight loss. Stay hydrated and consult your provider if you experience significant weight changes.
Can you take Ibsrela (tenapanor) after eating? It is recommended to take Ibsrela 5–10 minutes before meals for optimal effectiveness.
Is Ibsrela (tenapanor) a laxative? Yes, Ibsrela (tenapanor) functions as a laxative by drawing water into the intestines, which helps soften stool and increase bowel movements.
The content on this page is for informational and educational purposes only and does not constitute professional medical advice. Patients should not use the information presented on this page for diagnosing a health-related issue or disease. Before taking any medication or supplements, patients should always consult a physician or qualified healthcare professional for medical advice or information about whether a drug is safe, appropriate or effective.