Before taking spironolactone and hydrochlorothiazide,
tell your doctor and pharmacist if you are allergic to spironolactone, hydrochlorothiazide, thiazide diuretics (''water pills''), sulfa-based medications, penicillin, other medications, or any of the ingredients in spironolactone and hydrochlorothiazide tablets. Ask your pharmacist for a list of the ingredients.
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: aldosterone blocking medications such as eplerenone (Inspra), angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril (Capoten), enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (in Prinzide, in Zestoretic), moexipril (Univasc, in Uniretic), perindopril (Aceon), quinapril (Accupril, in Accuretic, in Quinaretic), ramipril (Altace), and trandolapril (Mavik, in Tarka); angiotensin II antagonists (angiotensin receptor blockers; ARBs) such as azilsartan (Edarbi, in Edarbyclor), candesartan (Atacand, in Atacand HCT), eprosartan (Teveten, in Teveten HCT), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, Benicar HCT), telmisartan (Micardis, in Micardis HCT, in Twynsta), and valsartan (Diovan, in Diovan HCT, Exforge); aspirin and other nonsteroidal anti-inflammatory medications (NSAIDS) such as ibuprofen (Advil, Motrin), indomethacin (Indocin, Tivorbex); cholestyramine (Prevalite); digoxin (Lanoxin); heparin and low molecular weight heparins such as enoxaparin (Lovenox); lithium (Lithobid); medications for diabetes or high blood pressure; potassium-sparing diuretics (''water pills'') such as amiloride (Midamor) or triamterene (Dyrenium, in Dyazide, in Maxzide); and potassium supplements. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
tell your doctor if you have high blood levels of calcium or potassium or have or ever had Addison's disease or other conditions that may cause high blood levels of potassium, or kidney or liver disease. Your doctor may tell you not to take spironolactone and hydrochlorothiazide.
tell your doctor if you have or have ever had asthma, systemic lupus erythematosus (SLE, a chronic inflammatory condition), diabetes, or gout.
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking spironolactone and hydrochlorothiazide, call your doctor.
if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking spironolactone and hydrochlorothiazide.
you should know that this medication may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.
remember that alcohol can add to the drowsiness caused by this medication.