Before taking levomilnacipran,
tell your doctor and pharmacist if you are allergic to levomilnacipran, milnacipran, any other medications, or any of the ingredients in the capsules. Ask your pharmacist for a list of the ingredients.
tell your doctor if you are taking a monoamine oxidase (MAO) inhibitors, including isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate) or if you have stopped taking an MAO inhibitor within the past 2 weeks or if you are taking linezolid (Zyvox) or methylene blue. Your doctor will probably tell you not to take levomilnacipran. If you stop taking levomilnacipran, you should wait at least one week before you start to take an MAO inhibitor.
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); antidepressants ('mood elevators') such as amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Adapin, Sinequan), imipramine (Tofranil), nortriptyline (Aventyl, Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil); aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin), and naproxen (Aleve, Naprosyn); buspirone (Buspar); clarithromycin (Biaxin, in Prevac); diuretics ('water pills'); fentanyl (Actiq, Duragesic, Fentora); ketoconazole (Nizoral); lithium (Eskalith, Lithobid); medications for mental illness such as clozapine (Clozaril) and haloperidol (Haldol); medications for migraine headaches such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), and zolmitriptan (Zomig); tramadol (Ultram); ritonavir (Norvir); and sibutramine (Meridia; no longer available in the United States. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with levomilnacipran, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
tell your doctor what herbal products and nutritional supplements you are taking, especially St. John's wort and tryptophan.
tell your doctor if you have or have ever had high blood pressure, urinary retention or problems urinating, low salt (sodium) levels in your blood, seizures, or kidney or heart disease.
tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking levomilnacipran, call your doctor.
avoid use of alcoholic beverages while you are taking levomilnacipran.
you should know that levomilnacipran may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.
you should know that levomilnacipran may cause high blood pressure. Your blood pressure should be checked regularly while you are receiving levomilnacipran.
you should know that levomilnacipran may cause angle-closure glaucoma (a condition where the fluid is suddenly blocked and unable to flow out of the eye causing a quick, severe increase in eye pressure which may lead to a loss of vision). Talk to your doctor about having an eye examination before you start taking this medication. If you have nausea, eye pain, changes in vision, such as seeing colored rings around lights, and swelling or redness in or around the eye, call your doctor or get emergency medical treatment right away.