Before taking sofosbuvir, velpatasvir, and voxilaprevir,
tell your doctor and pharmacist if you are allergic to sofosbuvir, velpatasvir, and voxilaprevir, any other medications, or any of the ingredients in the combination of sofosbuvir, velpatasvir, and voxilaprevir tablets. Ask your pharmacist for a list of the ingredients.
tell your doctor if you are taking rifampin (Rifadin, Rimactane, in Rifamate, in Rifater). Your doctor will probably tell you not to take sofosbuvir, velpatasvir, and voxilaprevir if you are taking rifampin.
tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amiodarone (Nexterone, Pacerone); cholesterol-lowering medications (statins) such as atorvastatin (Lipitor, in Caduet), fluvastatin (Lescol), lovastatin (Altoprev), pitavastatin (Livalo), pravastatin (Pravachol), rosuvastatin (Crestor), simvastatin (Flolipid, Zocor, in Vytorin); cyclosporine (Gengraf, Neoral, Sandimmune); dabigatran (Pradaxa); digoxin (Lanoxin); H2 blockers such as cimetidine (Tagamet), famotidine (Pepcid), nizatidine (Axid), and ranitidine (Zantac); certain medications for human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) including atazanavir (Reyataz), efavirenz (Sustiva, in Atripla), lopinavir (in Kaletra), tenofovir (Viread, in Atripla, Complera, Stribild, Truvada, others), and tipranavir (Aptivus) when taken with ritonavir (Norvir); imatinib (Gleevec); irinotecan (Camptosar); lapatinib (Tykerb); methotrexate (Otrexup, Rasuvo, Xatmep); mitoxantrone; rifabutin (Mycobutin); rifapentine (Priftin); certain medications for seizures such as carbamazepine (Carbatrol, Epitol, Equetro, Tegretol), oxcarbazepine (Trileptal), phenobarbital, or phenytoin (Dilantin, Phenytek); sulfasalazine (Azulfidine); topotecan (Hycamtin); and warfarin (Coumadin, Jantoven). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with sofosbuvir and velpatasvir, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
if you are taking aluminum or magnesium containing antacids (Maalox, Mylanta), take them 4 hours before or 4 hours after sofosbuvir, velpatasvir, and voxilaprevir.
tell your doctor what herbal products you are taking, especially St. John's wort.
tell your doctor if you have or have ever had any type of liver disease other than hepatitis C or kidney disease or if you are currently on dialysis.
tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking sofosbuvir, velpatasvir, and voxilaprevir, call your doctor.