Before taking elvitegravir, cobicistat, emtricitabine, and tenofovir,
tell your doctor and pharmacist if you are allergic to elvitegravir, cobicistat, emtricitabine, or tenofovir, any other medications, or any of the ingredients in elvitegravir, cobicistat, emtricitabine, and tenofovir tablets. Ask your pharmacist for a list of the ingredients.
tell your doctor if you are taking any of the following medications: alfuzosin (Uroxatral); carbamazepine (Carbatrol, Epitol, Tegretol, others), cisapride (Propulsid) (not available in the U.S.); ergot medications such as dihydroergotamine (D.H.E. 45, Migranal), ergotamine (Ergomar, in Cafergot, in Migergot), and methylergonovine (Methergine); lovastatin (Altoprev, Mevacor, in Advicor); lurasidone (Latuda); midazolam (Versed) by mouth; phenobarbital; phenytoin (Dilantin, Phenytek); pimozide (Orap); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); St. John's wort; sildenafil (only Revatio, brand used for lung disease); simvastatin (Simcor, Zocor, in Vytorin); or triazolam (Halcion). Your doctor will probably tell you not to take elvitegravir, cobicistat, emtricitabine, and tenofovir if you are taking one or more of these medications.
tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: aminoglycoside antibiotics such as gentamicin; antifungal medications such as itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), and voriconazole (Vfend); antiviral medications such as acyclovir (Sitavig, Zovirax), adefovir (Hepsera), cidofovir, ganciclovir (Cytovene), valacyclovir (Valtrex), and valganciclovir (Valcyte); aspirin and other nonsteroidal anti-inflammatory medications (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn) atorvastatin (Lipitor, in Caduet); benzodiazepines such as clonazepam (Klonopin), clorazepate (Gen-Xene, Tranxene), diazepam (Diastat, Valium), estazolam, flurazepam, and midazolam given intravenously (into a vein); beta blockers such as metoprolol (Lopressor, Toprol-XL, in Dutoprol) and timolol; bosentan (Tracleer); buspirone; calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Diltzac, Tiazac, others), felodipine (Plendil), nicardipine (Cardene), nifedipine (Adalat CC, Afeditab CR, Procardia), and verapamil (Calan, Covera-HS, in Tarka); clarithromycin (Biaxin, in PrevPac); colchicine (Colcrys, Mitagare, in Col-Probenecid); dexamethasone; ethosuximide (Zarontin), fluticasone (Flonase, Flovent, in Advair); oral contraceptives (birth control pills, patch, vaginal ring, or injectable); medications for depression such as amitriptyline, bupropion (Aplenzin, Forfivo XL, Wellbutrin, Zyban), desipramine (Norpramin), imipramine (Tofranil), nortriptyline (Pamelor), paroxetine (Brisdelle, Paxil, Pexeva), and trazodone; other medications for HIV or AIDS including adefovir (Hepsera), cobicistat (Tybost, in Evotaz, in Prezcobix), emtricitabine (Emtriva, in Atripla, in Complera, in Truvada), lamivudine (Epivir, in Combivir, in Epzicom, in Trizivir, others), ritonavir (Norvir, in Kaletra, in Technivie), and tenofovir (Viread, in Atripla, in Complera, in Truvada); medications for irregular heartbeat such as amiodarone (Cordarone, Nexterone, Pacerone), digoxin (Lanoxin), disopyramide (Norpace), flecainide, lidocaine (Xylocaine), mexiletine, propafenone (Rythmol), and quinidine (in Nuedexta); medications that suppress the immune system such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), and tacrolimus (Prograf); oxcarbazepine (Oxtellar XR, Trileptal); perphenazine; quetiapine (Seroquel); phosphodiesterase (PDE5) inhibitors such as sildenafil (Viagra), tadalafil (Adcirca, Cialis), and vardenafil (Levitra, Staxyn); rifabutin (Mycobutin); rifapentine (Priftin); risperidone (Risperdal); salmeterol (Serevent, in Advair); telithromycin (Ketek); thioridazine; warfarin (Coumadin, Jantoven); and zolpidem (Ambien, Edluar, Intermezzo, Zolpimist). Many other medications may also interact with elvitegravir, cobicistat, emtricitabine, and tenofovir, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
if you are taking antacids (Maalox, Mylanta, Tums, others), take them 2 hours before or 2 hours after elvitegravir, cobicistat, emtricitabine, and tenofovir.
tell your doctor if you have or have ever had the conditions mentioned in the IMPORTANT WARNING section, any type of infection that does not go away or that comes and goes such as tuberculosis (TB; a type of lung infection) or cytomegalovirus (CMV; a viral infection that may cause symptoms in patients with weak immune systems), or kidney disease.
tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking elvitegravir, cobicistat, emtricitabine, and tenofovir, call your doctor. You should not breastfeed if you are infected with HIV or if you are taking elvitegravir, cobicistat, emtricitabine and tenofovir.
you should be aware that your body fat may increase or move to different areas of your body, such as your upper back, neck (''buffalo hump''), breasts, and around your stomach. You may notice a loss of body fat from your face, legs, and arms.
you should know that while you are taking medications to treat HIV infection, your immune system may get stronger and begin to fight other infections that were already in your body. This may cause you to develop symptoms of those infections. If you have new or worsening symptoms during your treatment with elvitegravir, cobicistat, emtricitabine, and tenofovir, be sure to tell your doctor.