Qulipta (atogepant) trials showed that patients who took Qulipta against patients who took a placebo experienced a 7% decrease in body weight. More patients experience weight decrease when on the 10 mg prescription (3.8%) than on the 30 mg prescription (3.2%). And oddly, only 5.3% of patients on the 60 mg prescription experienced a weight decrease. However, those decreases in body weight aren’t the only reason for why someone may experience body mass index decline. Other reasons could be compounded by nausea, constipation, fatigue, decreased appetite, and dizziness.
Key Takeaways
Qulipta (atogepant) has been known to decrease body weight. With at least 7% of patients who took Qulipta (atogepant) against a trial of placebo pills experiencing this weight loss decrease.
Additional weight loss issues may come from the other compounding side effects that Qulipta (atogepant) causes. Those can include nausea, constipation, fatigue, decreased appetite, and dizziness. All of which can be contributors to someone consuming less food and ultimately, losing more body weight.
Qulipta and Weight Loss
Here’s what to know about Qulipta (atogepant) and weight loss side effects:
1. Qulipta does cause weight loss
According to clinical trials performed by AbbVie, Qulipta has been proven to show a 7% decrease in body weight when compared to patients who were taking placebo pills. According to the study, “In Study 1, Study 2, and Study 3, the proportion of patients with a weight decrease of at least 7% at any point was 2.5% for placebo, 3.8% for QULIPTA 10 mg, 3.2% for QULIPTA 30 mg, and 5.3% for QULIPTA 60 mg.”
This means that lower doses of Qulipta have not been proven to be effective in curbing any of the weight loss side effects.
2. Additional side effects can cause decreased body weight
Additional side effects such as nausea, constipation, and dizziness can also be strong contributors in a patient not wanting to eat and consume food. In addition, decreased appetite is another major contributing side effect that would cause weight loss.
In general, patients have been known to experience decreased food consumption from all of the combined side effects, increasing the weight loss chances and overall percentage of body mass that someone may lose.
3. Lower doses of Qulipta doesn’t curb weight loss side effects
Out of the 2,657 patients in the clinical trial, it showed that patients of varying ethnicities and ages, as well as dosages for their prescriptions didn’t curb any additional weight loss side effects and symptoms.
Patients who may want to curb this side effect more than others may want to speak with their primary care provider about a dosing schedule that could decrease the side effects based on your age, ethnicity, current health, and other prescriptions that could be playing a role in body weight decreases.
Related: Qulipta Side Effects
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Sources
Canadian Agency for Drugs and Technologies in Health. (2023, June). Atogepant (Qulipta): CADTH reimbursement recommendation. CADTH. https://www.ncbi.nlm.nih.gov/books/NBK595348/
U.S. Food and Drug Administration. (n.d.). QULIPTA (atogepant) prescribing information. https://www.accessdata.fda.gov/spl/data/a313e1c3-0edb-4e39-b069-0c538f0c9424/a313e1c3-0edb-4e39-b069-0c538f0c9424.xml
Rizzoli, P., Marmura, M. J., Robblee, J., McVige, J., Sacco, S., Nahas, S. J., Ailani, J., Ferreira, R. D. A., Ma, J., Smith, J. H., Dabruzzo, B., & Ashina, M. (2024). Safety and tolerability of atogepant for the preventive treatment of migraine: A post hoc analysis of pooled data from four clinical trials. The Journal of Headache and Pain, 25(1), 35. https://doi.org/10.1186/s10194-024-01736-z
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