Methylprednisolone vs. Prednisone (Similarities & Differences)

Key Takeaways

• Methylprednisolone is a corticosteroid hormone very similar to prednisone used to treat conditions such as arthritis, blood disorders, severe allergic reactions, certain cancers, eye conditions, skin/kidney/intestinal/lung diseases, and immune system disorders.

• There are no key distinguishable differences between the two substances other than methylprednisolone being a “stronger” form of the corticosteroid hormone.

Comparison of Methylprednisolone to Prednisone

Here is a general breakdown of methylprednisolone to prednisone:

In short, you can see that there are quite strong similarities between these two drugs. Methylprednisolone is simply more potent than prednisone.

Key Differences and Similarities

Here are some key differences and similarities between methylprednisolone and prednisone:

• Methylprednisolone and prednisone are both considered to be corticosteroids used to reduce inflammation and alleviate symptoms like pain, swelling, and stiffness.

• Both medications are standard treatments for autoimmune disorders like RA, thyroid issues, lupus, eczema, severe psoriasis, and allergic reactions.

• Methylprednisolone is considered to be stronger than prednisone, with methylprednisolone being “5X as potent” as cortisol, compared to prednisone's four times potency.

• Prednisone is primarily administered orally, whereas methylprednisolone can be given orally or via an injection site, which can be beneficial for severe inflammation requiring immediate reduction depending on the ailment the patient is dealing with.

• Proper dosage of both drugs is crucial. Primary care physicians may adjust dosage based on individual response and condition severity. Abrupt cessation can lead to withdrawal effects like nausea, fatigue, and joint pain.

• Side effects of both medications include a range of symptoms like headaches, nausea, acne, insomnia, mood swings, and vision problems. Prednisone may also cause psychosis in some cases.

• Corticosteroids can interact with various medications, and long-term use increases the risk of complications such as infections, cataracts, high blood pressure, and mental health issues.

• Methylprednisolone may be preferred for individuals with digestive issues hindering oral medication absorption. The choice between methylprednisolone and prednisone for the patient often depends on individual health conditions and the overall treatment goals.