According to an older study performed on Trazodone, “Trazodone has biphasic elimination, with a redistribution half-life of about one hour and an elimination half-life of 10-12 hours. Trazodone is nearly completely metabolized hepatically by hydroxylation and oxidation to metabolites that are probably inactive.”
Generally speaking, you can safely assume that Trazodone has a half-life of approximately 5 to 13 hours. For every 5 to 13 hours, the levels of Trazodone in your blood may drop by up to 50%. This will vary based on your body’s individual metabolic rate.
Key Takeaways
Trazodone has biphasic elimination, with a redistribution half-life of about one hour and an elimination half-life of 10-12 hours.
For every 5 to 13 hours, Trazodone levels will drop in your blood by up to 50% depending on your metabolic rate.
How Long Does Trazodone Stay in Your System?
Generally speaking, it will last anywhere from 5 to 13 hours. With studies showing that there’s an elimination half-life of 10-12 hours.
Your body’s personal metabolic rate will also determine the general half-life of any drug. There are a number of factors that might play a role in your body’s metabolic rate. Including:
Other drugs that you may currently be on
Your overall health and wellness
Your age
Your gender
Your body-mass-index (your weight)
The “healthier” that you are, the more opportunity that your liver has to detoxify your blood. Meaning, any substance or chemical compound that might be present in your blood can be moved through your bloodstream more quickly.
Ways to Detoxify Trazodone from Your System
There are no “secret” ways to detoxify your bloodstream from any particular substance. However, some basic rules can apply.
1. Drink Lots of Water
Try to drink a healthy amount of water according to your body-mass-index. This will help to keep your blood pressure in check and ensure that your liver is properly working to cleanse your system in a timely fashion.
2. Watch Your Diet
Foods like lemons, beets, apples, avocados, and other goods with lower acidic Ph levels can help in the process of detoxification. Watch out for processed carbohydrates as they’ll create fat-stores in your system and may not work to entirely cleanse your bloodstream. Leafy vegetables, whole grain, beans and peas are also great options.
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Sources
Bryant, S. G., & Ereshefsky, L. (1982). Antidepressant properties of trazodone. Clinical Pharmacy, 1(5), 406-417. https://pubmed.ncbi.nlm.nih.gov/6764164/
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