Epinephrine injection (common brand name EpiPen) is a life-saving medication used for the emergency treatment of severe allergic reactions (anaphylaxis) caused by insect stings or bites, foods, medications, and other allergens. Additionally, epinephrine is utilized in the treatment of critically low blood pressure (hypotension) resulting from septic shock.
Epinephrine, also known as adrenaline, is a hormone and neurotransmitter that acts on alpha-adrenergic and beta-adrenergic receptors in the body. Through this mechanism, epinephrine:
Relaxes the airway muscles, improving breathing and reversing wheezing.
Constricts blood vessels, increasing blood pressure to counteract hypotension.
Reduces severe itching, hives, and swelling, alleviating allergic reaction symptoms.
As a member of the sympathomimetic drug class, epinephrine mimics the effects of the body’s natural "fight-or-flight" response, making it essential for treating anaphylactic shock and hypotensive crises.
Epinephrine auto-injectors are preloaded, single-use devices designed for rapid administration in emergency situations. These devices are commonly prescribed for individuals with a history of severe allergic reactions and are intended for immediate self-administration or administration by a caregiver.
Key Takeaways
Brand-name EpiPen and generic equivalents can be purchased online from DrugMart.com, Amazon Pharmacy, Duration Health, PlushCare, Blink Health, Boots Online Doctor, and Walgreens.
EpiPen works by delivering epinephrine, which counteracts the life-threatening symptoms of severe allergies.
Common side effects include anxiety, dizziness, increased heart rate, and sweating. Serious side effects requiring immediate medical attention include difficulty breathing, chest pain, or swelling in the throat.
7 Places to Buy EpiPen Online (Epinephrine)
EpiPens are available through select certified pharmacies and telehealth providers. Below is a guide on where to obtain brand-name EpiPen and its generic equivalents.
Provider | Brand or Generic Equivalent | Consultation Required | Same-Day Prescription | Price |
Brand | No | No | 0.3mg/0.3ml solution syringe as low as $150.62 | |
Amazon Pharmacy | Generic Equivalent | Yes | No | $262.50 |
Duration Health | Brand | Yes | Yes | $839 |
PlushCare | Brand | Yes | Yes | $650 |
Blink RX/Blink Health | Generic Equivalent | No | No | $361.73 |
Boots Online Doctor | Brand & Generic Equivalent | Yes | Yes | As low as $176 |
Walgreens | Brand & Generic Equivalent | Yes | Yes | $597.72 |
Prices updated March 2025.
1. DrugMart.com
DrugMart is a CIPA-certified online pharmacy offering brand-name EpiPen at discounted rates. Customers can easily order their prescriptions online and have them shipped directly within the U.S.
Price: 0.3mg/0.3ml solution syringe as low as $150.62 Certification: CIPA-approved (Canadian International Pharmacy Association)
Pros:
Competitive pricing for brand-name EpiPen
Certified by CIPA for quality assurance
Reliable shipping to the U.S.
Cons:
Requires a prescription
No same-day pickup option
2. Amazon Pharmacy
Amazon Pharmacy provides generic epinephrine auto-injectors with a valid prescription. Customers can use FSA (Flexible Spending Account) and HSA (Health Savings Account) payments, making it a budget-friendly choice.
Pros:
Accepts FSA & HSA payments
Reliable online purchasing experience
Prescription transfer services available
3. Duration Health
Duration Health offers EpiPens as part of its emergency medical kits, making it a great option for travelers, outdoor adventurers, or individuals seeking long-term preparedness solutions.
Consultation Required: Yes
Same-Day Prescription: Yes
Subscription-Based Service
Pros:
Ideal for emergency preparedness and travel
Provides a full emergency medical kit
Fast prescription approval
Cons:
Requires an upfront medical consultation
More expensive than traditional pharmacy purchases
4. PlushCare
PlushCare is a telehealth service that connects patients with licensed physicians for EpiPen prescriptions through virtual consultations.
Consultation Required: Yes
Same-Day Prescription: Yes
Pros:
Convenient telehealth appointments
Access to licensed doctors nationwide
Same-day prescription availability
Cons:
Requires a paid consultation
Medication must be purchased separately from a pharmacy
5. Blink RX
Blink RX offers generic epinephrine auto-injectors at discounted prices, making it an affordable option for those with a valid prescription. Unlike some services, no online consultation is required.
Prescription Required: Yes
Pros:
Lower-cost alternative to brand-name EpiPen
No consultation needed
Available at various pharmacy locations
6. Boots Online Doctor (UK-Based)
Boots Online Doctor is a UK-based service providing both brand-name and generic equivalent EpiPens through virtual consultations.
Consultation Required: Yes
Same-Day Prescription: Yes
Pros:
Offers both brand-name and generic equivalent EpiPens
Online consultation simplifies the process
Available for immediate prescription approval
7. Walgreens
Walgreens Pharmacy offers EpiPen and generic equivalent alternatives both in-store and online. Prescriptions can be obtained through Walgreens’ telehealth services or from an external provider.
Consultation Required: Yes
Same-Day Prescription: Yes
Insurance Accepted
Pros:
Convenient in-store pickup available nationwide
Accepts insurance, making costs more affordable
Offers both brand-name and generic equivalent options
Available Dosages & Forms
EpiPen (Brand-Name Auto-Injector): 0.3 mg (for adults and children weighing 66 lbs or more)
EpiPen Jr.: 0.15 mg (for children weighing between 33 and 66 lbs)
Generic Epinephrine Auto-Injectors: Available in the same dosage strengths
Proper Storage of EpiPen
Store at room temperature (68°F to 77°F / 20°C to 25°C)
Avoid exposure to extreme heat or cold
Keep in original carrier tube to protect from light
Common Side Effects
EpiPen is generally safe when used correctly, but common side effects include:
Increased heart rate
Anxiety or nervousness
Dizziness
Sweating
Nausea
Serious Side Effects
While rare, serious side effects require immediate medical attention, including:
Difficulty breathing
Chest pain or irregular heartbeat
Severe allergic reaction to epinephrine itself
Common Questions and Answers About Epinephrine (EpiPen)
1. What is an EpiPen used for?
An EpiPen (epinephrine auto-injector) is used for the emergency treatment of severe allergic reactions (anaphylaxis) caused by insect stings, foods, medications, or other allergens. It helps reverse life-threatening symptoms such as difficulty breathing, low blood pressure, and severe swelling.
2. How does an EpiPen work?
The EpiPen delivers a single dose of epinephrine, which acts on the body's alpha and beta receptors to:
Open airways and relieve breathing difficulties.
Increase blood pressure by constricting blood vessels.
Reduce swelling, itching, and hives caused by allergic reactions.
3. Who should carry an EpiPen?
Anyone with a history of severe allergic reactions (anaphylaxis) should carry an EpiPen at all times. This includes individuals allergic to:
Certain foods (e.g., peanuts, shellfish)
Insect stings or bites
Medications (e.g., penicillin)
Latex or other known allergens
4. How should an EpiPen be stored?
Keep it at room temperature (68°F to 77°F / 20°C to 25°C).
Avoid extreme heat or cold—do not refrigerate or expose to direct sunlight.
Store in the protective carrier tube to prevent damage.
Check the expiration date regularly and replace it when it expires.
5. Can I reuse an EpiPen?
No, an EpiPen is single-use only. After use, seek emergency medical attention immediately and dispose of the used injector properly. If additional doses are needed, they must be administered using a second EpiPen.
6. How many EpiPens should I carry?
Doctors recommend carrying two EpiPens at all times in case a second dose is needed before emergency medical assistance arrives.
7. What is the cheapest place to buy an EpiPen online?
The most affordable place to purchase an EpiPen (0.3mg/0.3ml solution syringe) online is DrugMart.com, where prices start as low as $150.62.
Ready to purchase? Visit our page right here.
8. Can I get an EpiPen without a prescription?
No, EpiPens require a prescription in most countries, including the United States and Canada. You must consult a healthcare provider to obtain one.
9. What should I do after using an EpiPen?
Call 911 or emergency services immediately after using an EpiPen, even if symptoms improve.
Lie down with your legs elevated if experiencing dizziness or weakness.
A second dose may be needed if symptoms return before emergency help arrives.
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Sources
U.S. Food and Drug Administration. (2023). Epinephrine auto-injector prescribing information. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/019430s053lbl.pdf
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