Zofran (ondansetron) is a prescription medication used to prevent nausea and vomiting caused by surgery, chemotherapy, or radiation therapy. It works by blocking the action of serotonin, a natural chemical in the body that can trigger nausea and vomiting. Zofran (ondansetron) is available in several forms, including tablets, orally disintegrating tablets (ODT), and liquid, and may be prescribed to both adults and children over the age of four. It is often given before treatment begins and can be taken with or without food. In some cases, Zofran may be used off-label for other causes of nausea as determined by a healthcare provider.
While generally well-tolerated, Zofran (ondansetron) does carry some risks and should not be used by individuals taking apomorphine or those allergic to ondansetron or similar drugs like dolasetron or granisetron. Patients with liver disease, heart conditions, or a history of electrolyte imbalances should inform their doctor before starting Zofran (ondansetron). Potential side effects range from mild (such as headache or constipation) to serious, including blurred vision, irregular heartbeat, or serotonin syndrome—a potentially life-threatening condition.
Key Takeaways
Availability: Zofran (ondansetron) is available by prescription through licensed online pharmacies and telehealth platforms, including DrugMart, PlanetDrugsDirect, PlushCare, and RedBoxRX. Prices for a 30-tablet supply (mostly 8 mg) start under $20. DrugMart offers the lowest cost generic equivalent Zofran (ondansetron) at $18.80 (adjusted 30-tablet price). Purchase at DrugMart.com.
How It Works: Zofran (ondansetron) blocks serotonin, a natural chemical in the body that can trigger nausea and vomiting. It is commonly used before and after surgery, chemotherapy, or radiation, and is available in tablets, orally disintegrating tablets (ODT), and liquid form.
Common Side Effects: Most patients tolerate Zofran (ondansetron) well, but some may experience headache, drowsiness, diarrhea, constipation, or fatigue. Serious side effects—such as vision disturbances, irregular heartbeat, or serotonin syndrome—require immediate medical attention.
4 Places to Buy Zofran (Ondansetron) Online
Zofran (ondansetron) is a prescription anti-nausea medication used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, and surgery. It’s commonly prescribed in 4 mg or 8 mg tablet form and is available through licensed online pharmacies and telehealth platforms.
Price Comparison – Adjusted to 30 Tablets (8 mg unless noted)
Provider | Adjusted Price (30 Tablets) | Tablet Strength | Prescription Required | Link |
DrugMart | $18.80 | 8 mg | Yes | |
PlanetDrugsDirect | $19.19 | 8 mg | Yes | |
PlushCare | $30.00 | 4 mg | Yes | |
RedBoxRX | $37.50 | Varies | Yes |
Prices updated as of April 5, 2025. These reflect generic equivalents of Zofran unless otherwise noted. Final cost may vary slightly based on shipping or provider location.
Where to Buy Zofran (Ondansetron) Online
1. DrugMart
Offers one of the lowest available prices for generic equivalent Zofran, with U.S. shipping and straightforward delivery.
Adjusted Price: $18.80 for 30 tablets (8 mg)
Prescription Required: Yes
2. PlanetDrugsDirect
Provides international shipping and bulk options for generic equivalent Zofran at a competitive prices.
Adjusted Price: $19.19 for 30 tablets (8 mg)
Prescription Required: Yes
3. PlushCare
Telehealth platform offering ondansetron with a virtual consultation included. Pricing based on 4 mg tablets. Telehealth consultation may be an additional cost.
Adjusted Price: $30.00 for 30 tablets (4 mg)
Prescription Required: Yes
4. RedBoxRX
Online telehealth provider offering ondansetron and other treatments with variable strengths available. Telehealth consultation may be an additional cost.
Adjusted Price: $37.50 for 30 tablets (varied strength)
Prescription Required: Yes
What is Zofran (Ondansetron)?
Zofran (ondansetron) is an anti-nausea medication that works by blocking the action of serotonin, a natural substance in the body that can cause nausea and vomiting. It is commonly prescribed to prevent nausea and vomiting associated with surgery, chemotherapy, and radiation therapy.
In some cases, Zofran (ondansetron) may also be used for off-label purposes as determined by a healthcare provider.
Warnings
Do not use Zofran (ondansetron) if:
You are also taking apomorphine (Apokyn).
You are allergic to ondansetron or similar medications such as dolasetron, granisetron, or palonosetron.
You have phenylketonuria (PKU)—some Zofran tablets may contain phenylalanine.
Stop taking Zofran (ondansetron) and contact your doctor immediately if you experience:
Blurred vision or temporary vision loss
Severe dizziness or fainting
Chest pain or slow heart rate
Anxiety, agitation, or confusion
Shivering, muscle twitching
Decreased urination
Difficulty breathing
Zofran (ondansetron) may impair your thinking or reaction time. Be cautious when driving or operating machinery.
Before Taking Zofran (Ondansetron)
Tell your doctor if you have any of the following:
Liver disease
Electrolyte imbalances (low potassium or magnesium)
Congestive heart failure or slow heartbeats
A personal or family history of long QT syndrome
A blockage in your digestive tract
Pregnancy & Breastfeeding:
Zofran (ondansetron) is not expected to harm an unborn baby, but you should inform your doctor if you are pregnant. It is unknown whether ondansetron passes into breast milk—consult your doctor before breastfeeding.
Pediatric Use:
Not approved for use in children under 4 years old.
How to Take Zofran (Ondansetron)
Take exactly as prescribed by your doctor.
It can be taken with or without food.
The first dose is often given before surgery, chemotherapy, or radiation.
Use a full glass of water with regular tablets.
For orally disintegrating tablets (ODT):
Keep in the blister until ready to take.
Peel back the foil (do not push through).
Use dry hands, place in mouth, and let it dissolve.
Swallow naturally—do not chew or swallow whole.
Liquid form: Measure with the provided syringe or a proper measuring device.
Store at room temperature, away from heat and moisture. Keep liquid upright.
Missed Dose & Overdose
If you miss a dose, take it as soon as possible. Skip it if it's almost time for your next dose.
Do not take two doses at once.
In case of overdose, call Poison Help at 1-800-222-1222 or seek emergency care.
Symptoms may include: vision loss, fainting, severe constipation, or extreme dizziness.
Side Effects
Get emergency help if you show signs of an allergic reaction:
Rash or hives
Difficulty breathing
Swelling of face, lips, tongue, or throat
Call your doctor immediately if you experience:
Severe constipation or stomach pain
Jaundice (yellowing of skin or eyes)
Vision problems
Serotonin syndrome (agitation, fever, confusion, rapid heart rate, coordination problems)
Common side effects may include:
Headache
Diarrhea or constipation
Drowsiness
Tiredness
This is not a complete list. For more information, consult your doctor or pharmacist. Report side effects to the FDA at 1-800-FDA-1088.
Drug Interactions
Zofran (ondansetron) can interact with many other medications, potentially causing serious side effects, including heart rhythm problems and serotonin syndrome.
Tell your doctor about any of the following:
Antidepressants or antipsychotics
Heart medications
Opioids
HIV, cancer, or malaria treatments
Over-the-counter drugs, vitamins, or herbal products
Always inform your healthcare provider of all medications you are taking.
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Sources
U.S. Food and Drug Administration. (2016). Zofran (ondansetron hydrochloride) tablets, Zofran ODT (ondansetron) orally disintegrating tablets, and Zofran (ondansetron hydrochloride) oral solution: Prescribing information. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/020103s035_020605s019_020781s019lbl.pdf
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